Hemoglobin Body as a Novel Subcellular Structure Enhances Chondrocyte Hypoxia Adaption
Recent study indicates that massive amounts of hemoglobin,a known carrier of oxygen in eryth-rocytes,is produced in chondrocyte,where it can form a new structure hedy(hemoglobin body)by liquid-liquid phase separation.The production of hemoglobin in chondrocytes turns out to be dependent on Klf1 rather than the classical Hif1/2α pathway.Hemoglobin depletion leads to enhanced hypoxia that causes extensive cell death in the center of cartilaginous tissue.These results demonstrate uncover a heretofore unrecognized mechanism whereby chondrocytes survive a hypoxic environment on hedy,an oxygen storage for emergency supply.
NETL
NSTL
万方数据
