Tuberculosis,induced by Mtb(Mycobacterium tuberculosis),is characterized by caseating granuloma formation in response of immunopathological damages.The molecular mechanism underlying the tu-berculosis is complex.ApoA-Ⅰ(Apolipoprotein A1),as a non-glycosylated plasma protein,is anti-inflammatory and antioxidant,able to regulate cholesterol transport,and autophagy,to be involved in various other diseases.The as-sociation between ApoA-Ⅰ and pathogenesis of tuberculosis has attracted extensive attention lately.This article will review the role of ApoA-1 in the tuberculosis development and related biological signaling pathway,which will complete the pathogenesis of tuberculosis and provide a clue for possible strategy of treatment for tuberculosis.
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