PDAC(pancreatic ductal adenocarcinoma)is a common malignant tumor of the digestive sys-tem.Because it lacks clear symptoms in the early stages and is typically detected in the late and metastatic stages,it is difficult to cure and has a high death rate.Glycosylation is an important post-translational modification of pro-teins.The most common types are O-glycosylation and N-glycosylation.The protein glycosylation is closely related to the tumorigenesis of pancreatic cancer,especially plays a key role in the process of pancreatic cancer metasta-sis.Abnormal glycosylation modification can promote the metastasis of pancreatic cancer by changing epithelial-mesenchymal transition and tumor microenvironment.Therefore,it is of great significance to elucidate the role of glycosylation modification in the metastasis of pancreatic cancer cells.This article reviews the basic structure of glycosylation and its regulatory role in pancreatic cancer metastasis.
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