Extracellular Vesicles-Based Diagnostic and Therapeutic Applications for Graft-Versus-Host Disease
GvHD(graft-versus-host disease)is one of the most common life-threatening complications after allo-HSCT(allogeneic hematopoietic stem cell transplantation).EVs(extracellular vesicles)are nanometer-to-micron sized biofilm vesicles containing a variety of active ingredients,such as proteins,nucleotides,lipids,and metabolites.In recent years,studies have shown that there are unique differences in serum-derived EVs components in patients after allo-HSCT,so EVs has potential diagnostic and prognostic values.In addition,cell-free therapies,represented by EVs derived from MSCs(mesenchymal stem cells),have shown significant therapeutic efficacy in pre-clinical treat-ment studies of GvHD.This paper not only summarizes the clinical translational value of EVs in GvHD diagnosis and treatment,but also reviews the latest progress and future prospects of engineered EVs in GvHD,in order to provide a new strategy and theoretical basis for customized and personalized combination therapy with less toxic side effects.
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