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植物细胞外囊泡研究进展

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细胞外囊泡(extracellular vesicles,EVs)是一类具有脂质膜包被的囊泡,其内包裹着蛋白质、脂质、RNA等活性大分子,由细胞分泌到质外体,对细胞间的交流至关重要.哺乳动物研究显示EVs广泛参与了细胞间通讯、肿瘤的发生和转移、免疫应答等多种生理过程.与之相比,植物EVs的研究相对滞后,近年来研究发现EVs在植物发育、抗病、植物与微生物共生等方面发挥重要作用.该文对真核生物EVs的研究进行了总结,着重梳理了植物EVs的发生、功能鉴定和分泌机制等方面的进展,并对植物EVs研究的关键问题和应用前景进行了展望.
Research Progress and Perspectives of Extracellular Vesicles in Plants
EVs(extracellular vesicles)are membrane-bound vesicles released by cells into the extracel-lular space,facilitating the transfer of proteins,lipids,nucleic acids,and metabolites between cells.Consequently,they have emerged as crucial mediators of intercellular communication.The fundamental roles of EVs have been extensively studied in a wide range of physiological and pathological contexts in mammals,including intercellular signaling,tumorigenesis and metastasis,and immune responses.Despite the extensive research on EVs in mam-mals,plant EVs have not been thoroughly investigated.However,it has become increasingly clear that plant EVs fulfill various cellular functions in development,plant defense,and symbiosis.This article provides an overview of recent advances in plant EVs research and compares them with findings in mammals.Specifically,it focuses on the functional characteristics of plant EVs and the molecular mechanisms underlying their secretion.Additionally,this review discusses the future directions and prospects of plant EVs research.

plantsEVs(extracellular vesicles)exosomeMVBs(multivesicular bodies)EXPO(exocyst positive organelle)

赵淑举、黄佳欣、李师鹏、蒋苏

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齐鲁师范学院生命科学学院,济南 250200

植物 细胞外囊泡 外泌体 多囊泡体 EXPO

山东省自然科学基金

ZR2020MC067

2024

中国细胞生物学学报
中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,中国细胞生物学学会

中国细胞生物学学报

CSTPCD
影响因子:0.554
ISSN:1674-7666
年,卷(期):2024.46(6)
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