The Therapeutic Effect of hPSC Derived Oligodendrocyte Precursor Cells on Spinal Cord Injury
SCI(spinal cord injury)is a devastating CNS(central nervous system)disorder that often results in severe functional impairments.Due to the incomplete understanding of its underlying pathophysiological mecha-nisms,SCI remains a global medical challenge.In recent years,the in-depth understanding of the role of OPC(oligodendrocyte progenitor cell)in the CNS has led to the emergence of cell therapy as a promising strategy.Ex-tensive animal experiments have shown that OPC transplantation into injured spinal cord promotes remyelination and significantly improves motor function.This review provides a foundation of knowledge regarding OPC-based treatment for SCI,summarizes the existing research findings,and identifies the challenges encountered in clinical applications.It serves as a basis for further research and development of effective therapeutic strategies.
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