hPSC源少突胶质前体细胞用于脊髓损伤的治疗作用
The Therapeutic Effect of hPSC Derived Oligodendrocyte Precursor Cells on Spinal Cord Injury
潘辉 1鲍莉 1纪猛 2张锋 3吴月红1
作者信息
- 1. 浙江理工大学,生命科学与医药学院,杭州 310018
- 2. 浙江泉生生物工程有限公司,研发部,杭州 310018
- 3. 浙江泉生生物工程有限公司,研发部,杭州 310018;霍尔果斯新生泉干细胞医疗有限公司,研发部,伊犁哈萨克自治州 835221
- 折叠
摘要
脊髓损伤(spinal cord injury,SCI)是一种严重的中枢神经系统(central nervous system,CNS)疾病,常导致严重的功能障碍,因其病理生理机制尚不完全清楚,仍为世界性的医学难题.随着对少突胶质前体细胞(oligodendrocyte progenitor cell,OPC)在CNS中作用的深入研究,以此为基础的细胞疗法成为一种有最具前景的治疗策略.动物实验结果表明,OPC移植到损伤脊髓可促进髓鞘再生、改善运动功能.该文介绍了关于OPC治疗SCI的基本情况,总结了已有的研究成果,指出了其在临床应用中面临的挑战,从而为进一步研究和开发有效的治疗策略提供了依据.
Abstract
SCI(spinal cord injury)is a devastating CNS(central nervous system)disorder that often results in severe functional impairments.Due to the incomplete understanding of its underlying pathophysiological mecha-nisms,SCI remains a global medical challenge.In recent years,the in-depth understanding of the role of OPC(oligodendrocyte progenitor cell)in the CNS has led to the emergence of cell therapy as a promising strategy.Ex-tensive animal experiments have shown that OPC transplantation into injured spinal cord promotes remyelination and significantly improves motor function.This review provides a foundation of knowledge regarding OPC-based treatment for SCI,summarizes the existing research findings,and identifies the challenges encountered in clinical applications.It serves as a basis for further research and development of effective therapeutic strategies.
关键词
少突胶质前体细胞/脊髓损伤/临床试验/脱髓鞘/髓鞘再生Key words
oligodendrocyte precursor cell/spinal cord injury/clinical trial/demyelination/remyelination引用本文复制引用
基金项目
伊犁哈萨克自治州科学技术计划(YKX2023A11)
伊犁哈萨克自治州科学技术计划(YKX2024A01)
出版年
2024
NETL
NSTL
万方数据