外泌体影响急性胰腺炎多脏器损伤的研究进展
Research Progress on Effects of Exosomes on Multiple Organ Injury in Acute Pancreatitis
连源 1白敏 1汪湛东 1张钰 1王琼 1汪永锋 2郭超 3宋冰 3张延英3
作者信息
- 1. 甘肃中医药大学,兰州 730000
- 2. 甘肃中医药大学,兰州 730000;甘肃医学院,平凉 744000
- 3. 甘肃中医药大学,兰州 730000;甘肃省实验动物行业技术中心,兰州 730000
- 折叠
摘要
急性胰腺炎(acute pancreatitis,AP)是临床常见的急腹症,以胰腺为发病中心,随着病程的发展可诱导机体产生全身性炎症反应,累及肺、肠、肝脏及肾脏等身体多个器官.外泌体是由细胞产生的携带多种活性物质的细胞外囊泡,可充当细胞间信息交流的介质.近年来研究发现临床AP患者血浆外泌体存在显著特异性改变,相关基础研究进一步揭示了外泌体在AP多脏器损伤中的关键作用.该文就外泌体的生物发生过程及其在AP多脏器损伤中的作用机制进行综述,以进一步明确其影响AP多脏器损伤的具体机制,为AP临床治疗提供新的方向.
Abstract
AP(acute pancreatitis)is a clinically common acute abdominal disorder centered on the pan-creas that over the course of the disease can induce systemic inflammation that affects multiple organs of the body,including the lungs,intestines,liver,and kidneys.Exosomes are extracellular vesicles produced by cells that carry a variety of active substances and can act as mediators for information exchange between cells.Recent studies have found significant specific changes in plasma exosomes in patients with clinical AP,and relevant basic studies have further revealed the key role of exosomes in AP multiple organ injury.In this paper,the biogenetic process of exo-somes and the mechanism of action in AP multiple organ injury were reviewed,so as to further clarify the specific mechanism of exosomes affecting AP multiple organ injury,and provided a new direction for clinical treatment of AP.
关键词
外泌体/急性胰腺炎/多脏器损伤/发病机制Key words
exosome/acute pancreatitis/multiple organ injury/pathogenesis引用本文复制引用
基金项目
国家自然科学基金(82360898)
国家自然科学基金(82160871)
甘肃省自然科学基金(22JR5RA591)
甘肃省中医药管理局重点项目(GZKZ-2021-10)
出版年
2024
NETL
NSTL
万方数据