线粒体自噬在老年术后认知功能障碍中的机制研究进展
Advances in Research on the Mechanism of Mitophagy in Postoperative Cognitive Dysfunction in the Elderly
高宁 1王喜军 1黄刚 1赵思琪1
作者信息
- 1. 广西中医药大学附属国际壮医医院,麻醉科,南宁 530201
- 折叠
摘要
线粒体自噬是一种选择性自噬形式,通过消除受损或功能异常的线粒体,维持细胞稳态.术后认知功能障碍是老年患者接受麻醉手术后的一种常见神经系统并发症.由于我国人口老龄化加剧,术后认知功能障碍在老年患者中的发病率越来越高,探讨其发病机制并制定有效的治疗方案显得尤为重要.目前研究表明,线粒体自噬相关信号通路的失调在术后认知功能障碍的发生发展中有重要作用.因此,该文描述了线粒体自噬的生理过程及功能,总结了PINK1/Parkin、mtDNA/cGAS/STING、PKR/STAT3信号通路通过影响线粒体自噬功能参与术后认知功能障碍的发生过程,为从线粒体自噬角度对术后认知功能障碍进行防治提供了理论依据.
Abstract
Mitophagy is a selective form of autophagy that plays a crucial role in maintaining cellular homeostasis by eliminating damaged or dysfunctional mitochondria.POCD(postoperative cognitive dysfunc-tion)is a prevalent neurological complication observed in elderly patients undergoing anesthesia and surgical procedures.Given the rising prevalence of POCD in the elderly population,it is imperative to investigate its underlying pathophysiology and develop efficacious therapeutic strategies.Current studies suggest that dys-regulation of mitophagy-related signaling pathways significantly contributes to the development and occurrence of postoperative cognitive dysfunction.Accordingly,this manuscript delineates the physiological mechanisms and roles of mitochondrial autophagy,collating the influences of the PINK1/Parkin,mtDNA/cGAS/STING,and PKR/STAT3 signaling pathways on the modulation of mitochondrial autophagy function and their involvement in the emergence of postoperative cognitive impairment.This provides a theoretical framework for the prophylaxis and therapeutic strategies targeting postoperative cognitive dysfunction through the perspective of mitochondrial autophagy.
关键词
线粒体自噬/术后认知功能障碍/PTEN诱导激酶1/帕金森病蛋白信号通路/干扰素刺激基因/转录激活因子3Key words
mitophagy/postoperative cognitive dysfunction/PINK1/parkin signaling pathway/stimulator of interferon genes/activator of transcription 3引用本文复制引用
基金项目
广西国际壮医医院自然科学研究基金(GZ2021011)
广西国际壮医医院自然科学研究基金(GZ2021054)
广西国际壮医医院特色学科项目(GZ2023103)
出版年
2024
NETL
NSTL
万方数据