铜死亡在肝细胞癌中的研究进展
Research Progress of Cuproptosis in Hepatocellular Carcinoma
黄圆 1苏亚珍 1王昌荣 1关勇宇 2刘芳 1陈彻1
作者信息
- 1. 甘肃中医药大学公共卫生学院,兰州 730000
- 2. 甘肃省妇幼保健院临床检验中心,兰州 730000
- 折叠
摘要
铜死亡(cuproptosis)是新近发现的一种铜依赖性并与线粒体呼吸相关的程序性细胞死亡形式.过量的铜通过干扰线粒体三羧酸循环(tricarboxylic acid cycle,TCA)和引发蛋白质毒性应激的方式导致细胞死亡.铜代谢和铜死亡与肿瘤的发生发展密切关联,而肝脏是人体内铜储存和排出的主要器官.在肝癌细胞中诱导铜死亡是一种很有前景的治疗方法,探究铜死亡与肝细胞癌之间的联系,有助于寻找新的有效治疗策略.因此,该文讨论了铜死亡与肝细胞癌发生发展和预后的相关性,并总结了与铜死亡相关的肝细胞癌治疗方法,以期为肝细胞癌的诊断、治疗和研究提供参考.
Abstract
Cuproptosis is a newly discovered copper-dependent form of programmed cell death related to mitochondrial respiration.Excessive copper leads to cell death by interfering with mitochondrial tricarboxylic acid cycle and triggering protein toxic stress.Copper metabolism and cuproptosis are closely related to the occurrence and development of tumors.The liver is the main organ in the body where copper is stored and excreted.Inducing cuproptosis in hepatocellular carcinoma cells is a promising therapeutic approach,and exploring the relationship between cuproptosis and hepatocellular carcinoma is helpful to find new and effective therapeutic strategies.There-fore,this paper discusses the correlation between cuproptosis and the occurrence,development and prognosis of he-patocellular carcinoma,and summarizes the therapeutic methods of hepatocellular carcinoma related to cuproptosis,in order to provide references for the diagnosis,treatment and research of hepatocellular carcinoma.
关键词
铜死亡/铜代谢/肝细胞癌/靶向治疗/预后Key words
cuproptosis/copper metabolism/hepatocellular carcinoma/targeted therapy/prognosis引用本文复制引用
基金项目
甘肃省科技计划青年科技基金(22JR11RA124)
甘肃中医药大学科学研究与创新基金(2022KCYB-2)
兰州市科技计划(2023-2-12)
甘肃省中医药研究中心开放课题项目(zyzx-2023-06)
出版年
2024
NETL
NSTL
万方数据