Suspension Culture Technology of Mammalian Cells and Its Application
Suspension culture technology involves suspending cells in a culture medium,which is uti-lized for virus propagation or protein expression.This technology is often utilized for purposes such as virus proliferation or protein expression.It has several advantages,including scalability for scale-large cell culture,high expression levels of target products,high quality of products and advantage for industrial application.Vari-ous cell types have been successfully adapted to suspension cultures through the use of suitable bioreactors,mi-crocarriers,and serum-free media.These cells are currently being utilized in a range of applications,including inactivated virus vaccine production,recombinant proteins and cell therapy.This review provides an in-depth analysis of mammalian cell suspension culture domestication technology and its applications in the fields of in-activated virus vaccines,recombinant proteins,and cell therapy.By providing insights into the development and application of suspension culture technology,this review aims to serve as a valuable resource for researchers in this field.
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