沉默信息调节因子2(silent information regulator 2,SIRT2)作为长寿蛋白是沉默信息调节因子家族中的一员,是一种依赖于烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)的去乙酰化酶.近年来,越来越多的研究证实SIRT2参与心血管疾病的发生发展,其结构和功能与心血管相关性疾病的联系也逐渐被揭示.该文主要综述了SIRT2在调节机体生物学效应中发挥的关键作用,阐述了其在动脉粥样硬化、心肌缺血再灌注损伤、心肌梗死与心力衰竭等心血管相关性疾病中的内在机制,并总结了目前SIRT2相关激动剂和抑制剂的研究进展,为寻找心血管疾病的潜在治疗靶点提供新思路.
Research Progress on the Relationship between SIRT2 and Cardiovascular Disease
As a long-lived protein,SIRT2(silent information regulator 2)is a member of the silent infor-mation regulator family and a deacetylase dependent on NAD+(nicotinamide adenine dinucleotide).In recent years,a growing body of research has confirmed the involvement of SIRT2 in the development of cardiovascular diseases,and the structure and function of SIRT2 have been gradually established to be associated with cardiovascular-relat-ed diseases.This article mainly reviews the key role of SIRT2 in regulating the biological effects of the organism,elucidates its intrinsic mechanism in cardiovascular-related diseases such as atherosclerosis,myocardial ischemia-reperfusion injury,myocardial infarction,and heart failure,and summarizes the current research progress on SIRT2-related agonists and inhibitors,which will provide a new way of thinking to search for the potential therapeutic targets of cardiovascular diseases.
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