Ago(Argonaute)is a protein family widely present in various organisms.In eukaryotic organ-isms,Ago is the core component of silencing complexes in RNAi(RNA interference)processes.It is an RNA endonuclease guided by a small RNA(21 nt in length)that specifically degrades its paired RNA.In prokaryotes,there are numerous Agos,compared to eAgo(eukaryotic Ago),pAgo(prokaryotic Ago)exhibits diversity,but there is a lack of research on its functions.Recent studies have found that short pAgo,which accounts for the majority of pAgo,can exert its anti-phage function in various ways.This article summarizes recent research regarding anti-phage functios and molecular mechanisms of short pAgo,providing reference value for the functional research of other short pAgo.
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