IVDD(intervertebral disc degeneration)is a common spinal disease,and its pathogenesis is cur-rently not fully understood.Inflammatory cells such as neutrophils,macrophages,and inflammatory chemokines such as TNF-α,IL-1β,and IL-6 can promote apoptosis and degradation of nucleus pulposus cells in degenerated intervertebral discs,leading to IVDD.In addition,inflammatory cytokines can also stimulate chondrocyte endplate cells to produce a series of inflammatory mediators,triggering an inflammatory response.In terms of signaling pathways,NF-κB,MAPK,and PI3K/Akt signaling pathways have been found to play key roles in the IVDD pro-cess,regulating the expression of inflammatory cytokines and participating in the regulation of the survival and metabolism of annulus fibrosus cells.Therefore,interventions targeting inflammatory cytokines and their related signaling pathways may become a new approach for treating IVDD.In summary,inflammatory cytokines and related signaling pathways play an important role in IVDD,and in-depth research on them will help to find new methods for treating IVDD.This review aims to explore the role of inflammatory cytokines in IVDD and the regu-latory mechanisms of related signaling pathways,and systematically summarize the intervention measures based on inflammatory response in IVDD.
关键词
脊柱疾病/椎间盘退变/炎症细胞因子/作用机制/信号通路
Key words
spinal diseases/intervertebral disc degeneration/inflammatory cytokines/mechanism of action/signaling pathway
维普
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