Genetic lineage tracing technology has become an important tool for uncovering cell origins and determining cell fate.In recent years,significant advancements have been made in this field,with researchers successfully constructing and optimizing a range of new genetic lineage tracing technologies,such as those medi-ated by dual recombinases.These emerging technologies provide invaluable tools for in-depth studies of cell pro-liferation,differentiation,and transdifferentiation phenomena during tissue regeneration.Using these technologies,researchers have successfully revealed key cell subpopulations and core signal transduction pathways during tissue regeneration.This article is dedicated to summarizing the development of these new genetic lineage tracing tech-nologies and their applications in tissue regeneration research,such as in the liver regeneration,providing insights and references for studies on cell fate determination,tissue regeneration,and applications in regenerative medicine.Expanding the use of these novel genetic lineage tracing techniques can propel the research level in this field,and thereby optimize and innovate methods for studying cell fate determination,threreby advancing the development of regenerative medicine.
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