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基于微环境调控的多发性硬化症髓鞘再生策略

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多发性硬化症(multiple sclerosis,MS)是一种因免疫系统攻击髓鞘而引发的炎性脱髓鞘疾病.髓鞘再生对神经功能的恢复至关重要,但在MS患者中,这一过程常被阻碍.随着对髓鞘再生的微环境影响逐渐被揭示,研究人员开始关注其在MS中的作用机制.理解并调控MS中的微环境,可能为开发新的治疗策略提供新的思路.该文总结了髓鞘再生的微环境调控研究进展,探讨了不同微环境因子如何影响髓鞘再生及其对未来MS治疗的潜在意义.
Myelin Regeneration Strategy for Multiple Sclerosis Based on Microenvironment Regulation
MS(multiple sclerosis)is an inflammatory demyelinating disease caused by the immune system attacking the myelin sheath.Myelin regeneration is crucial for the recovery of nerve function,but in MS patients,this process is often hindered.As the influence of the microenvironment on myelin regeneration is gradually re-vealed,researchers begin to pay attention to its mechanism of action in MS.Understanding and regulating the mi-croenvironment in MS may provide new ideas for developing new treatment strategies.This article summarizes the research progress in the microenvironment regulation of myelin regeneration and discusses how different microen-vironmental factors affect myelin regeneration and its potential significance for future MS treatment.

multiple sclerosismicroenvironmentoligodendrocytesmyelin regeneration

金书棋、罗富成、崔健臣

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昆明理工大学灵长类转化医学研究院,省部共建非人灵长类生物医学国家重点实验室,昆明 650500

云南省第一人民医院麻醉科,昆明 650032

昆明理工大学附属医院麻醉科,昆明 650032

多发性硬化症 微环境 少突胶质细胞 髓鞘再生

2024

中国细胞生物学学报
中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,中国细胞生物学学会

中国细胞生物学学报

CSTPCD
影响因子:0.554
ISSN:1674-7666
年,卷(期):2024.46(11)