Advances in the Relationship between PLAC and Placenta-Mediated Pregnancy Disorders
李连春 1朱真仪 1杨好 1杨永康 2李勤2
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作者信息
1. 陕西中医药大学第二临床医学院,咸阳 712046
2. 陕西中医药大学第二附属医院,咸阳 712000
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摘要
胎盘特异性家族蛋白(placenta-specific family protein,PLAC)是一类胎盘特异性表达的蛋白,主要通过调控胎盘的形成、胚胎的植入、滋养细胞和胚胎干细胞的功能,促进胎盘和胎儿的生长发育,确保妊娠的顺利进展.近年来,越来越多的关于PLAC在胎盘源性妊娠疾病中的表达变化备受关注,与健康孕妇之间存在显著差异,相关蛋白和基因表达异常可能与胎盘功能障碍和疾病发生风险相关.该文探讨PLAC与胎盘源性妊娠疾病关系和作用机制,其可能成为妊娠疾病的潜在生物标志物,有望用于疾病的诊断和预防.
Abstract
PLAC(placenta-specific family protein)is a class of placenta-specific expressed protein that promote placental and fetal growth and development,and ensure the smooth progression of pregnancy by regulat-ing placental formation,embryo implantation,and the function of trophoblast and embryonic stem cells.In recent years,more and more attention has been paid to the changes in expression of PLAC family protein in placenta-me-diated pregnancy disorders,with significant differences between them and healthy pregnant women,and abnormali-ties in the expression of related proteins and genes that may be associated with the risk of placental dysfunction and disease development.It is important to explore the relationship and mechanism of action of PLAC family protein with placenta-mediated pregnancy disorders,and they may be potential biomarkers for pregnancy disorders,which are expected to be used for diagnosis and prevention of diseases.
关键词
胎盘特异性蛋白/胎盘发育/滋养细胞/胎盘源性妊娠疾病
Key words
placenta-specific family protein/placental development/trophoblast/placenta-mediated preg-nancy disorders
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