自身免疫性疾病是一系列由于免疫系统错误地攻击自身组织或器官引起的疾病,与免疫细胞过度激活有关.T细胞免疫球蛋白及黏蛋白结构域分子-3(T cell immunoglobulin and mu-cin domain-containing protein-3,Tim-3)作为一种免疫检查点分子,可以通过与不同的配体结合来调节免疫细胞的功能,在自身免疫性疾病中发挥免疫调节的作用.该综述总结了Tim-3的结构和生物学功能、Tim-3与不同配体间的相互作用、Tim-3在自身免疫性疾病中的研究进展,讨论了Tim-3作为靶点的免疫治疗前景,为Tim-3在自身免疫性疾病中的应用提供新思路.
Research Progress of Tim-3 in Autoimmune Diseases
Autoimmune diseases are a series of diseases caused by the immune system mistakenly attack-ing its own tissues or organs,which are related to the excessive activation of immune cells.Tim-3(T cell immuno-globulin and mucin domain-containing protein-3)is an immune checkpoint molecule.It can regulate the function of immune cells by binding to different ligands,and play an immunomodulatory role in autoimmune diseases.This review summarizes the structure and biological function of Tim-3,the interaction between Tim-3 and different li-gands,and the research progress of Tim-3 in autoimmune diseases.The prospect of Tim-3 as a target for immuno-therapy is discussed,which provides new ideas for the application of Tim-3 in autoimmune diseases.
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