首页|脂质代谢异常与癌症:诊断与治疗前景

脂质代谢异常与癌症:诊断与治疗前景

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近年来,越来越多证据证明脂质代谢异常在癌症发生和发展中的关键作用,特别是脂质代谢异常导致的脂质积累,通过为癌细胞提供能源、重塑膜结构、参与信号转导等途径促进癌症的发生与发展,为癌症提供了重要的优势条件.该文主要从脂肪酸和胆固醇代谢方面介绍了脂质积累对癌症发展和治疗耐药性的作用与机制,癌细胞中的脂质如何积累以及脂质代谢途径的解析为癌症诊断和治疗提供的潜在策略.
Abnormal Lipid Metabolism and Cancer:Diagnosis and Treatment Prospects
In recent years,more and more evidences have proved that abnormal lipid metabolism plays a key role in the occurrence and development of cancer.In particular,lipid accumulation caused by abnormal lipid metabolism promotes the occurrence and development of cancer by providing energy for cancer cells,remodeling membrane structure,participating in signal transduction,and other ways,providing important advantages for can-cer.This article mainly introduces the effects and mechanisms of lipid accumulation on cancer development and drug resistance from the aspects of fatty acid and cholesterol metabolism,as well as how lipids accumulate in can-cer cells and the analysis of lipid metabolic pathways,providing potential strategies for cancer diagnosis and treat-ment.

cancerlipid metabolismtargeted therapy

杨馨雅、周悦思、韩英伦

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辽宁师范大学生命科学学院,大连 116081

辽宁师范大学七鳃鳗研究中心,大连 116081

大连工业大学海洋食品精深加工关键技术省部共建协同创新中心,大连 116034

癌症 脂质代谢 靶向治疗

2024

中国细胞生物学学报
中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,中国细胞生物学学会

中国细胞生物学学报

CSTPCD
影响因子:0.554
ISSN:1674-7666
年,卷(期):2024.46(12)