Progress on the Role of Striatal A2AR in the Prevention and Treatment of Parkinson's Disease by Exercise
A2AR(adenosine 2A receptor)is specifically expressed in neurons of the striatal indirect pathway and plays an important"integrated"role in the regulation of striatal-dependent programmed behavior.Excessive activation of the indirect pathway under PD(Parkinson's disease)pathology is associated with A2AR overexpression in the striatum.However,A2AR-specific antagonists have unique cognitive-promoting functions and neuroprotective effects while improving dyskinesia in PD patients.Various types of exercise therapy have received increasing attention for their positive effects in improving PD-related behavioral dysfunction,which show positive effects in neuroprotection,anti-inflammation,anti-oxidative stress,regulating neurotransmitter expression in the central nervous system and promoting neuroplasticity,and can significantly affect striatal A2AR expression levels.Starting with A2AR,this paper elaborates the possible role of A2AR in the prevention and treat-ment of PD neurodegeneration and PD movement,providing a theoretical basis for the development of new tar-geted drugs for PD and the study of neurobiological mechanisms,and providing a reference for the improvement and promotion of non-invasive physical therapy.
NETL
NSTL
万方数据
