机械负荷调节骨形成的非编码RNA机制研究进展
Advances in Non-Coding RNA Mechanisms of Mechanical Loading Regulating Bone Formation
王谦 1蔺俊斌 1夏露1
作者信息
- 1. 武汉大学中南医院康复医学科,武汉 430071
- 折叠
摘要
骨组织作为一种力学反应性组织,能对机械负荷的刺激作出反应.机械负荷能够通过调控细胞内复杂的信号转导影响骨的形成和吸收.研究显示非编码RNA(non-coding RNA,ncRNA)在机械负荷调控骨形成和吸收的过程中发挥重要作用.其中,长链非编码RNA(long non-coding RNA,lncRNA)和miRNA(microRNA)等多种ncRNAs协同参与各类通路的调控,进而参与机械负荷条件下骨形成的调节.该文总结了参与机械负荷调控的关键ncRNAs及其通路,旨在明确机械负荷通过调控相关ncRNAs调节骨形成的具体内在机制,为未来进一步应用机械负荷促进成骨分化提供理论依据,也为相关骨形成异常有关疾病的治疗提供思路.
Abstract
Bone tissue,as a mechanically responsive tissue,is able to respond to stimulation by mechanical loading.Mechanical loading can affect bone formation and resorption by regulating complex intracellular signaling.Studies have shown that ncRNA(non-coding RNA)plays an important role in the regulation of bone formation and resorption by mechanical loading.Among them,lncRNA(long non-coding RNA),miRNA and other ncRNAs are involved in the regulation of various pathways in a synergistic manner,which in turn are involved in the regulation of bone formation under mechanical loading conditions.This papersummarized the key ncRNAs and their pathways involved in the regulation of mechanical loading,aiming to clarify the specific intrinsic mechanism by which me-chanical loading regulates bone formation through the modulation of ncRNAs,which provides a theoretical basis for the further application of mechanical loading to promote osteogenic differentiation,as well as a reference for the treatment of diseases related to abnormalities in bone formation.
关键词
机械应力/非编码RNA/lncRNA/miRNA/骨形成Key words
mechanical stress/non-coding RNA/lncRNA/miRNA/bone formation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据