Research Progress on the Regulation of Microglia Function by Biological Clock
The biological clock is an internal system that autonomously generates rhythms with a cycle of approximately 24 h,regulating and coordinating various physiological activities,behavioral patterns,and metabolic processes.This system aligns the organism with the diurnal and nocturnal variations in the environment,thereby main-taining internal homeostasis and enhancing the organism's ability to adapt to external conditions.In the immune sys-tem of animals,the biological clock precisely regulates the quantity,activity,and function of immune cells,influencing their diurnal variations in inflammatory responses,modulating the temporal expression of immune-modulatory mol-ecules,and impacting the formation,maintenance,and timing strategies for the treatment of immune-related diseases.Microglia,as key immune cells,play a critical role in innate immune responses through surveillance and regulation,and their activity and function are finely controlled by the biological clock mechanism.This article provides a review of recent advances in research on the regulation of microglial function by the biological clock.
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