Research progress on immunotherapy based on NK cells for hepatocellular carcinoma
Hepatocellular carcinoma(HCC)is well characterized as a heterogeneous disease.Its late-stage diagnosis and chemotherapy resistance make it one of the refractory tumors in China.Natural killer(NK)cells play a significant role in immune surveillance.However,NK cells become dysfunctional in the progression of HCC,leading to tumor immune escape.This article reviews the recent progress on different strategies of NK cell-based immunotherapy in treating HCC,including direct adoptive NK cell transfer,gene engineering in NK cell,NK cell receptor targeting,immunosuppressive microenvironment modification,and tumor toxicity enhancement by cytokines or traditional Chinese medicine.These NK cell-based strategies have shown promising therapeutic potential.
NETL
NSTL
万方数据
