首页|癌相关成纤维细胞与M2型巨噬细胞相互作用促进肿瘤发生发展的研究进展

癌相关成纤维细胞与M2型巨噬细胞相互作用促进肿瘤发生发展的研究进展

扫码查看
癌相关成纤维细胞(CAF)是肿瘤微环境(TME)中主要成分之一.在TME中,肿瘤细胞与非肿瘤细胞之间或非肿瘤细胞与非肿瘤细胞之间的相互作用能促进肿瘤发生发展.CAF可与多种免疫细胞之间产生相互作用,通过抑制适应性免疫细胞功能,重塑TME中免疫微环境促进肿瘤的发生发展.其中CAF与巨噬细胞相互作用,并诱导巨噬细胞向M2型极化在促进肿瘤发生发展中起到重要作用.
Research progress of interaction between CAFs and M2 macrophages to promote tumor progression
Cancer associated fibroblasts(CAFs)are one of the main components of tumor microenvironment(TME).In TME,the interaction between tumor cells and non-tumor cells or among non tumor cells can promote the occurrence and development of tumors.CAFs can interact with a variety of immune cells and promote the occurrence and development of tumors by inhibiting the function of adaptive immune cells and reshaping the immune microenvironment in TME.The interaction between CAFs and macrophages and the induction of macrophage polarization towards M2 type play an important role in promoting tumor occurrence and development.This article reviews the research progress of CAF in promoting the polarization of M2 macrophages.

cancer-associated fibroblasts(CAFs)M2-polarized macrophagestumor microenvironment(TME)review

吴江为、张巧玲、杨泽羊、张瑞、张舰、曾柱、吴介恒

展开 >

贵州医科大学免疫学教研室,贵州贵阳 550025

空军军医大学基础医学院免疫学教研室,陕西西安 710032

贵州医科大学附属医院胸外科,贵州贵阳 550001

癌相关成纤维细胞(CAF) M2型巨噬细胞 肿瘤微环境(TME) 细胞相互作用 综述

国家自然科学基金地区科学基金国家自然科学基金重点项目贵州省科技厅基础研究计划贵州医科大学国科金培养项目

8216056612132006黔科合基础-ZK[2021]一般11820NSP002

2024

细胞与分子免疫学杂志
中国免疫学会,第四军医大学

细胞与分子免疫学杂志

CSTPCD北大核心
影响因子:0.817
ISSN:1007-8738
年,卷(期):2024.40(2)
  • 71