癌相关成纤维细胞与M2型巨噬细胞相互作用促进肿瘤发生发展的研究进展
Research progress of interaction between CAFs and M2 macrophages to promote tumor progression
吴江为 1张巧玲 1杨泽羊 1张瑞 2张舰 3曾柱 1吴介恒2
作者信息
- 1. 贵州医科大学免疫学教研室,贵州贵阳 550025
- 2. 贵州医科大学免疫学教研室,贵州贵阳 550025;空军军医大学基础医学院免疫学教研室,陕西西安 710032
- 3. 贵州医科大学附属医院胸外科,贵州贵阳 550001
- 折叠
摘要
癌相关成纤维细胞(CAF)是肿瘤微环境(TME)中主要成分之一.在TME中,肿瘤细胞与非肿瘤细胞之间或非肿瘤细胞与非肿瘤细胞之间的相互作用能促进肿瘤发生发展.CAF可与多种免疫细胞之间产生相互作用,通过抑制适应性免疫细胞功能,重塑TME中免疫微环境促进肿瘤的发生发展.其中CAF与巨噬细胞相互作用,并诱导巨噬细胞向M2型极化在促进肿瘤发生发展中起到重要作用.
Abstract
Cancer associated fibroblasts(CAFs)are one of the main components of tumor microenvironment(TME).In TME,the interaction between tumor cells and non-tumor cells or among non tumor cells can promote the occurrence and development of tumors.CAFs can interact with a variety of immune cells and promote the occurrence and development of tumors by inhibiting the function of adaptive immune cells and reshaping the immune microenvironment in TME.The interaction between CAFs and macrophages and the induction of macrophage polarization towards M2 type play an important role in promoting tumor occurrence and development.This article reviews the research progress of CAF in promoting the polarization of M2 macrophages.
关键词
癌相关成纤维细胞(CAF)/M2型巨噬细胞/肿瘤微环境(TME)/细胞相互作用/综述Key words
cancer-associated fibroblasts(CAFs)/M2-polarized macrophages/tumor microenvironment(TME)/review引用本文复制引用
基金项目
国家自然科学基金地区科学基金(82160566)
国家自然科学基金重点项目(12132006)
贵州省科技厅基础研究计划(黔科合基础-ZK[2021]一般118)
贵州医科大学国科金培养项目(20NSP002)
出版年
2024
NETL
NSTL
万方数据