Research progress on HLA-G in non-small cell lung cancer
Human leukocyte antigen G(HLA-G)belongs to the non-classic major histocompatibility complex class Ⅰ b(MHC Ⅰ b)molecule,including membrane and soluble isoforms.HLA-G regulates the function of various immune cells through corresponding receptors.It is one of the important immunological mechanisms of matemal-fetal tolerance and tumor immune escape.Non-small cell lung cancer(NSCLC)patients account for the highest proportion of lung cancer patients and have poor prognoses.Studies have shown that the gene polymorphism and expression level of HLA-G is closely related to the occurrence and development of NSCLC.It is suggested that HLA-G can be used as a potential biomarker for the early diagnosis,subtype differentiation,treatment,and prognosis of NSCLC patients.HLA-G has clinical value as an auxiliary diagnostic basis.An in-depth study of its mechanism can provide new strategies for the diagnosis and treatment of NSCLC patients.
human leukocyte antigen-G(HLA-G)HLA-G polymorphismnon-small cell lung cancer(NSCLC)immune escapebiomarkersreview
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