环鸟苷酸-腺苷酸合成酶(cGAS)翻译后修饰在固有免疫中的研究进展
Advances in post-translational modifications of cGAS in innate immunity
韦雅芳 1刘纪实 1李怡素 1潘诗琪 1唐又周1
作者信息
- 1. 中南大学湘雅三医院肾内科,湖南长沙 410013
- 折叠
摘要
环鸟苷酸-腺苷酸合成酶(cGAS)作为一种核酸转移酶,主要通过感受核酸、激活下游通路并调控Ⅰ型干扰素的合成参与固有免疫反应.cGAS蛋白功能的调节与细菌病毒感染、自身免疫系统疾病及肿瘤等多种疾病相关,而翻译后修饰是目前研究最深入和广泛的cGAS蛋白功能调节方式之一.cGAS蛋白翻译后修饰主要有磷酸化、乙酰化、泛素化、小泛素相关修饰(SUMO)化、肽链剪切及谷氨酰化.本文不但系统总结了不同生理和病理条件下cGAS的翻译后修饰如何调控cGAS功能,而且深入挖掘了以cGAS翻译后修饰作为疾病治疗靶点的潜力.
Abstract
As a member of the nucleotidyltransferase family,cyclic guanosine monophosphate-adenosine monophosphate synthase(cyclic GMP-AMP synthase,or cGAS)is primarily involved in innate immunity as a nucleic acids sensor that activates its downstream pathway and regulates type Ⅰ interferon synthesis.The regulation of cGAS function is correlated with the bacterial and viral infections,autoimmune diseases,tumors,and other diseases.Besides,post-translational modification is one of the most in-depth and extensive ways of cGAS function adjustment.There are mainly six types of post-translational modifications(PTMs)of cGAS,including phosphorylation,acetylation,ubiquitination,sumoylation,peptide chain cleavage,and glutamylation.This article not only systematically summarizes how PTMs of cGAS regulate the functions of cGAS under different physiological and pathological conditions,but also probes deep into the potential of PTMs as therapeutic targets.
关键词
翻译后修饰/环鸟苷酸-腺苷酸合成酶(cGAS)/固有免疫/综述Key words
post-translational modifications/cyclic GMP-AMP synthase(cGAS)/innate immunity/review引用本文复制引用
基金项目
国家自然科学基金(82070738)
湖南省自然科学基金(2021JJ31015)
湖南省卫生健康委项目(202103050563)
湖南省卫生健康委项目(202104022248)
中南大学教育教学改革项目(2020)(2020jy172)
出版年
2024
NETL
NSTL
万方数据