铁死亡在肿瘤免疫中的作用研究进展
Research progress on ferroptosis in tumor immunity
吉江红 1刘赛 1廖翔 1王冬青 1朱海涛1
作者信息
- 1. 江苏大学附属医院影像科,江苏镇江 212000
- 折叠
摘要
铁死亡(ferroptosis)是由亚铁离子和脂质过氧化物过量堆积所导致的新型细胞死亡模式,能够以自噬依赖的方式释放损伤相关分子模式,作为免疫原性细胞死亡的佐剂,激活适应性免疫和固有免疫.肿瘤细胞和免疫细胞铁死亡受多种因素的调控且相互影响,对肿瘤的发展、治疗和预后起着重要作用.文中总结了肿瘤微环境中,T细胞、巨噬细胞、中性粒细胞、B细胞等免疫细胞与肿瘤细胞铁死亡之间的相关生物学效应.
Abstract
Ferroptosis is a novel form of cell death that is induced by excessive accumulation of ferrous ions and lipid peroxides.It triggers the release of damage-associated molecular patterns through autophagy-dependent mechanisms,serving as an adjunct to immunogenic cell death and activating both adaptive and innate immunity.In the tumor microenvironment,the regulation and influence of tumor cells and immune cells undergoing ferroptosis are regulated by various factors,which plays a crucial role in tumor development,treatment,and prognosis.This article provides an overview of the biological effects of ferroptosis on immune cells such as T cells,macrophages,neutrophils and B cells and tumor cells in the tumor microenvironment.
关键词
铁死亡/免疫原性细胞死亡/免疫细胞/损伤相关分子模式/综述Key words
ferroptosis/immunogenic cell death/immune cells/damage-associated molecular patterns/review引用本文复制引用
基金项目
国家自然科学基金(82071984)
江苏省基础研究计划(BK20191223)
江苏省研究生实践创新计划(2021)(SJCX21_1723)
出版年
2024
NETL
NSTL
万方数据