Toll样受体2(TLR2)与结核分枝杆菌感染的相关研究进展
Research progress on Toll-like receptor 2(TLR2)with Mycobacterium tuberculosis infection
陈瑞枫 1王瑄 2马枫茜 1周鑫沛 3吴利先1
作者信息
- 1. 大理大学基础医学院微生物学与免疫学教研室,云南大理 671000
- 2. 南昌大学玛丽女王学院,江西南昌 330031
- 3. 大理大学基础医学院人体解剖学教研室,云南大理 671000
- 折叠
摘要
Toll样受体2(TLR2)是白细胞表面表达的一种模式识别受体,已发现多种配体可以激动或抑制TLR2的活化,进而调控免疫细胞的炎症和凋亡状态.结核分枝杆菌(MTB)通常寄生在巨噬细胞中,但MTB感染机体后,包括巨噬细胞在内的多种免疫细胞表面的TLR2都可与其相互作用,释放细胞因子,影响MTB在体内的状态和增殖.在分子层面,TLR2的多态性有待更多探索,目前研究的大部分TLR2的多态性被认为与MTB的易感性无关.文中总结了TLR2与配体、感染后免疫调节活动、多态性与MTB易感性等方面的研究进展.
Abstract
Toll-like receptor 2(TLR2)is a pattern recognition receptor expressed on the surface of leukocytes.Various ligands can activate or inhibit TLR2,therefore regulating the inflammation and apoptosis of immune cells.Mycobacterium tuberculosis(MTB)typically parasitizes macrophages.Further,after infecting the body,MTB can interact with TLR2 on the surface of various immune cells,including macrophages,leading to the release of cytokines that can affect the state and proliferation of MTB in the body.Additional research is needed to understand the polymorphism of TLR2 at the molecular level.Current studies indicate that the majority of TLR2 polymorphisms are not associated with susceptibility to MTB infection.This review provides an overview of the researches related to TLR2 and its ligands,the immune regulation activities of TLR2 following MTB infection,and the association of TLR2 polymorphism with susceptibility to MTB.
关键词
结核分枝杆菌(MTB)/Toll样受体2(TLR2)/细胞因子/多态性/综述Key words
Mycobacterium tuberculosis(MTB)/Toll-like receptor 2(TLR2)/cytokine/polymorphism/review引用本文复制引用
基金项目
国家自然科学基金(81260456)
云南省地方本科高等学校基础研究重点项目(202101BA07111-038)
出版年
2024
NETL
NSTL
万方数据