Th17细胞与IL-17在桥本甲状腺炎中的研究进展
The role of Th17 cells and IL-17 in Hashimoto's thyroiditis:Review
高晓莉 1马德寿 2江彤 3李嘉桢2
作者信息
- 1. 郑州大学第二附属医院急诊科,河南郑州 450000
- 2. 青海大学附属医院乳腺甲状腺外科,青海西宁 810001
- 3. 青海大学附属医院内分泌科,青海西宁 810001
- 折叠
摘要
桥本甲状腺炎患者血清与甲状腺组织内17型辅助T(Th17)细胞数量增多、白细胞介素17(IL-17)水平显著升高,且Th17细胞与调节性T细胞(Treg)比例失衡.Treg比例下降导致甲状腺内免疫抑制功能降低,而Th17细胞通过分泌IL-17等调节甲状腺内促炎细胞因子表达和介导甲状腺组织纤维化参与桥本甲状腺炎的发生发展.
Abstract
Patients with Hashimoto's thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue,significantly elevated levels of interleukin 17(IL-17),and an imbalance in the ratio of Th17 cells to regulatory T cells(Tregs).The reduced Tregs'ratio leads to a reduction in immunosuppressive function within the thyroid gland,while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
关键词
桥本甲状腺炎/17型辅助T(Th17)细胞/白细胞介素17(IL-17)/调节性T细胞(Treg)/作用机制/综述Key words
Hashimoto's thyroiditis/Th17 cells/IL-17/regulatory T cells(Tregs)/mechanism/review引用本文复制引用
基金项目
青海省科技厅项目(2019-ZJ-7091)
出版年
2024
NETL
NSTL
万方数据