The role of Th17 cells and IL-17 in Hashimoto's thyroiditis:Review
Patients with Hashimoto's thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue,significantly elevated levels of interleukin 17(IL-17),and an imbalance in the ratio of Th17 cells to regulatory T cells(Tregs).The reduced Tregs'ratio leads to a reduction in immunosuppressive function within the thyroid gland,while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
Hashimoto's thyroiditisTh17 cellsIL-17regulatory T cells(Tregs)mechanismreview
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