三种人乳头瘤病毒疫苗接种后T、B细胞应答差异的研究进展
Research progress on the differences between T and B cell responses to three different forms of human papilloma virus(HPV)vaccination
彭芪 1李洋洋 1李俊 1姚新生1
作者信息
- 1. 遵义医科大学免疫学教研室,贵州遵义 563000
- 折叠
摘要
宫颈癌是全球女性常见癌症之一,高危型人乳头瘤病毒16(HPV16)、HPV18的长期感染是宫颈癌的主要病因,目前广泛应用的HPV疫苗主要有2价Cervarix疫苗、4价Gardasil疫苗及9价Gardasil-9疫苗,三种疫苗接种后在T细胞效应分子变化,B细胞产生的抗体水平、持续时间、年龄及接种针剂等方面存在差异.
Abstract
One of the most prevalent malignancies in women is cervical cancer.Cervical cancer is mostly brought on by chronic high-risk human papillomavirus 16(HPV16)and HPV18 infection.Currently,the widely used HPV vaccines are the bivalent Cervarix,the tetravalent Gardasil,and the 9-valent Gardasil-9.There are differences in T cell effector molecule changes,B cell antibody level,duration,age and the injection after vaccination of the three vaccines.
关键词
人乳头瘤病毒(HPV)/HPV疫苗/T细胞/B细胞/免疫应答/综述Key words
human papilloma virus(HPV)/HPV vaccine/T cell/B cell/immune response/review引用本文复制引用
出版年
2024
NETL
NSTL
万方数据