肿瘤相关巨噬细胞在宫颈癌中的研究进展
Research progress of tumor-associated macrophages in cervical cancer
李丹 1卢艳1
作者信息
- 1. 广西医科大学附属肿瘤医院妇瘤科,广西南宁 530021
- 折叠
摘要
肿瘤相关巨噬细胞(TAM)在肿瘤微环境(TME)中可以分化为M1型和M2型巨噬细胞表型,其中M2型巨噬细胞在恶性肿瘤中发挥重要作用.在宫颈癌中,TAM加重人乳头瘤病毒(HPV)感染,促进肿瘤细胞增殖、侵袭和迁移,促进脉管形成,诱导免疫耐受.靶向TAM的治疗已成为宫颈癌免疫治疗的热点.
Abstract
Tumor-associated macrophages(TAM)can be differentiated into M1-type and M2-type macrophage phenotypes in the tumor microenvironment(TME),with M2-type macrophages playing a crucial role in malignant tumors.In cervical cancer,TAM exacerbates human papilloma virus(HPV)infection,promotes the proliferation,invasion,and metastasis of tumor cells,stimulates angiogenesis,and induces immune tolerance.TAM targeting strategies have emerged as a hot topic in cervical cancer immunotherapy.
关键词
宫颈癌/肿瘤相关巨噬细胞/肿瘤微环境/细胞极化/免疫治疗/综述Key words
cervical cancer/tumor-associated macrophages/tumor microenvironment/cell polarization/immunotherapy/review引用本文复制引用
出版年
2024
NETL
NSTL
万方数据