Application of chimeric antigen receptor macrophage(CAR-M)therapy in the treatment of inflammation-associated depression
The classic Chimeric Antigen Receptor Macrophage(CAR-M)exerts pro-inflammatory effects to achieve anti-tumor immunity,but by modifying the structure design of CAR,it can acquire anti-inflammatory functions similar to M2,thereby treating inflammatory diseases.Currently,CAR-M therapy targeting M1-type microglial cells can effectively reduce neuroinflammation and be used to treat inflammation-related depression.With ongoing research on the anti-inflammatory effects of CAR-M,CAR-M cell therapy offers a new approach for treating inflammatory-related diseases.
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