Research progress of MCP-1 in the pathogenesis of Alzheimer's disease
Alzheimer's disease(AD)is a neurodegenerative disorder with an insidious onset,primarily characterized by a progressive decline in cognitive function.MCP-1 is a cytokine with chemotactic effects on monocytes,which can regulate their migration and infiltration and participate in disease progression.Increasing evidence suggests that MCP-1 plays a key role in the progression of Alzheimer's disease and has the potential to act as an early diagnostic marker and intervention target.This paper reviews the regulatory role of MCP-1 in neuroinflammation,beta-amyloid(Aβ)deposition and Tau pathology,and explores the potential of MCP-1 as a biomarker and intervention target for the early diagnosis of Alzheimer's disease.
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