Cancer immunotherapy including immune checkpoint inhibitors and adoptive cell therapy has gained revolutionary success in the treatment of hematologic tumors;however,it only gains limited success in solid tumors.For example,chimeric antigen receptor T(CAR-T)cell therapy has shown significant effects and potential for curing patients with B-cell malignancies.In contrast,it remains a challenge for CAR-T cell therapy to gain similar success in solid tumors.The anti-tumor effect of endogenous or adoptively transferred tumor-specific T cells depends largely on their differentiation status.T cells at early differentiation stage show better anti-tumor therapeutic effects than fully differentiated effector T cells.In cancer patients,the persistence of tumor-specific T cells with the stem cell memory or precursor phenotype is significantly associated with improved therapeutic outcomes;therefore,adoptively transfered CAR-T cells with stem cell memory and/or central memory is expected to gain better anti-tumor effects.Herein we focused on the in vitro optimized culture and expansion system to obtain CAR-T cells with stem cell memory or central memory phenotype for the review.
关键词
肿瘤免疫治疗/嵌合抗原受体T细胞/过继细胞疗法/干细胞记忆T细胞/代谢适应性/表观遗传调控/综述
Key words
Tumor immunotherapy/chimeric antigen receptor T cells/adoptive cell therapy/stem cell memory T cells/metabolic fitness/epigenetic regulation/review
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