首页|RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions,cancer-associated long noncoding RNAs and aberrant alternative splicings

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions,cancer-associated long noncoding RNAs and aberrant alternative splicings

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  • NETL
  • NSTL
  • 万方数据
There are remarkable disparities among patients of different races with prostate cancer; however,the mechanism underlying this difference remains unclear.Here,we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese population using RNA-seq,revealing tremendous diversity across prostate cancer transcriptomes with respect to gene fusions,long noneoding RNAs (long ncRNA),alternative splicing and somatic mutations.Three of the 14 tumors (21.4％) harbored a TMPRSS2-ERG fusion,and the low prevalence of this fusion in Chinese patients was further confirmed in an additional tumor set (10/54=18.5％).Notably,two novel gene fusions,CTAGE5-KHDRBS3 (20/54=37％) and USP9Y-TTTY15(19/54=35.2％),occurred frequently in our patient cohort.Further systematic transcriptional profiling identified numerous long ncRNAs that were differentially expressed in the tumors.An analysis of the correlation between expression of long ncRNA and genes suggested that long ncRNAs may have functions beyond transcriptional regulation.This study yielded new insights into the pathogenesis of prostate cancer in the Chinese population.

prostate cancerRNA sequencinggene fusionslong ncRNAsalternative splicing

Shancheng Ren、Zhiyu Peng、Jian-Hua Mao、Yongwei Yu、Changjun Yin、Xin Gao、Zilian Cui、Jibin Zhang、Kang Yi、Weidong Xu、Chao Chen、Fubo Wang、Xinwu Guo、Ji Lu、Jun Yang、Min Wei、Zhijian Tian、Yinghui Guan、Liang Tang、Chuanliang Xu、Linhui Wang、Xu Gao、Wei Tian、Jian Wang、Huanming Yang、Jun Wang、Yinghao Sun

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Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Beijing Genomics Institute at Shenzhen, Shenzhen, Guangdong 518083, China

Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA

Department of Pathology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Department of Urology, Jiangsu Provincial People's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

Department of Urology

the Third Affiliated Hospital of Sun Yat Sen University,Guangzhou, Guangdong 510630, China

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国家重点基础研究发展规划(973计划)Ministry of Science & Technology of ShanghaiNational Natural Science Fundation of ChinaNational High Technology Research and Development Program of China (863 Program)

2012CB518300 to YHS08410701500 to YHS81101946 to SCR2006AA02A302 to HMY

2012

10.1038/cr.2012.30

细胞研究(英文版)
中国科学院上海生化细胞所

细胞研究(英文版)

CSTPCDCSCDSCI
影响因子：1.355
ISSN：
年,卷(期)：2012.22(5)
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