摘要
目的 探讨伏诺拉生联合高剂量阿莫西林新二联七天方案治疗幽门螺杆菌(Hp)感染的应用价值.方法 纳入2022年4月-2023年4月在我院诊断为Hp感染的患者共260例,随机分为观察组130例和对照组130例.观察组接受伏诺拉生联合高剂量阿莫西林新二联七天方案,对照组接受雷贝拉唑联合高剂量阿莫西林二联两周方案.治疗结束后至少4周再次复查13C尿素呼气试验,阴性者表示成功根除.比较两组患者的一般资料、不良反应发生率、Hp根除率、治疗费用和服药依从性.分别采用意向性治疗(ITT)和符合方案集(PP)分析不同方案的Hp的根除效果.结果 260例患者中共有221例患者完成治疗、随访和复查,其中观察组109例,对照组112例.两组患者的一般资料和不良反应发生率比较无统计学差异(P＞0.05).ITT和PP分析,两组的Hp根除率比较差异无统计学意义(P＞0.05).治疗费用对比,观察组方案价格低廉、药物经济效益更优.服药依从性方面,观察组显著高于对照组(P＜0.05).结论 伏诺拉生联合高剂量阿莫西林新二联七天方案在治疗Hp感染中效果确切、不良反应少,同时具有治疗费用低和患者服药依从性高的特点,在未来有望成为根除Hp感染的一种新的方案和选择.
Abstract
Objective To explore the application value of a new dual seven day regimen of vonolaxan combined with high-dose Amoxicillin in the treatment of Helicobacter pylori(H.pylori)infection.Methods A total of 260 patients with H.pylori infection diagnosed in Dongguan Songshan Lake Tungwah Hospital from June 2021 to June 2022 were se-lected and randomly divided into a study group of 130 cases and a control group of 130 cases.The study group received the new 7-day regimen of vonolaxan combined with high-dose Amoxicillin,while the control group received the two-week regimen of Rabeprazole combined with high-dose Amoxicillin.Repeat the 13C urea breath test at least 4 weeks after treat-ment,and a negative result indicates successful eradication.Compare the general information,incidence of adverse reac-tions,eradication rate of H.pylori,treatment costs,and medication compliance between the two groups of patients.In-tention to treat(ITT)and per protocol(PP)were used to analyze the eradication effects of H.pylori with different regi-mens,respectively.Results A total of 221 out of 260 patients completed treatment,follow-up,and review,including 109 in the study group and 122 in the control group.There was no statistically significant difference in general informa-tion and incidence of adverse reactions between the two groups of patients(P＞0.05).ITT and PP analysis showed that the eradication rates of H.pylori in the study group and control group were 72.6％,90.0％,and 74.1％,91.5％,respective-ly,with no statistically significant difference(P＞0.05).Comparison of treatment costs,the research group's plan has lower prices and better drug economic benefits.In terms of medication compliance,the study group was significantly higher than the control group(P＜0.05).Conclusion The new dual seven day regimen of vonolaxan combined with high-dose Amoxicillin is effective in the treatment of H.pylori infection,with few adverse reactions,low cost and high com-pliance of patients.It is expected to become a new scheme and option for the eradication of H.pylori infection in the future.
维普
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