Effect and correlation of serum vitamin D level on elderly patients with chronic obstructive pulmonary disease complicated with pulmonary embolism
Objective To investigate the correlation between serum vitamin D level and pulmonary embolism(PE)in elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 200 elderly patients with COPD hospitalized in the First Affiliated Hospital of Medical College of Shihezi University School from January 2019 to December 2020 were selected,including 31 cases with PE as group A and 169 cases with COPD alone as group B.Mean-while,100 healthy elderly outpatients or inpatients were selected as control group C.Serum vitamin D level,Padua score and pulmonary function were measured in each patient.Results The serum levels of vitamin D,FEV1 and FEV1/FVC in COPD combined with PE group and COPD group were significantly lower than those in control group,and the COPD combined with PE group was significantly lower than that in COPD group.Compared with the control group,the Padua score of COPD combined with PE group and COPD group was observably higher,and the COPD combined with PE group was markedly higher than the COPD group,the differences were statistically significant(all P＜0.05).Correlation analy-sis showed that vitamin D was positively correlated with FEV1/FVC(r=0.365,P＜0.05),and negatively correlated with Padua score(r=-0.254,P＜0.05).Multivariate unconditional Logistic regression analysis showed that vitamin D、Padua score、smoking were independent influencing factor for PE in elderly COPD patients.Conclusion The lower the vi-tamin D level in elderly COPD patients,the more likely they may be more prone to PE.Serum vitamin D level is positive-ly correlated with FEV1 and FEV1/FVC,and negatively correlated with Padua score after admission.Low level of vita-min D,high Padua score and smoking are independent risk factor for PE in elderly patients with COPD.
Chronic obstructive pulmonary diseaseVitamin DPulmonary embolismPadua scorePulmonary function
万方数据
维普
