摘要
目的 探究慢阻肺合并肺部感染(PI)影响因素及血清白细胞介素-16(IL-16)、CD40、高迁移率族蛋白B1(HMGB1)变化.方法 回顾性分析2020年7月-2023年6月于本院接受治疗的113例慢阻肺患者临床资料,根据是否发生PI分为感染组34例和非感染组79例.收集患者一般资料,比较两组患者血清IL-16、CD40、HMGB1水平,采用单因素及Logistics回归分析慢阻肺患者发生PI的危险因素.结果 慢阻肺患者中PI发病率为30.09％(34/113);PI组IL-16、CD40、HMGB1水平均高于非PI组(均P＜0.05);Logistics回归分析显示,吸烟史、糖尿病史、住院时间≥15 d、长期使用抗生素、机械通气、IL-16、CD40、HMGB1是慢阻肺发生PI的独立危险因素(均P＜0.05).结论 吸烟史、糖尿病史、住院时间≥15 d、长期使用抗生素、机械通气IL-16、CD40、HMGB1是慢阻肺发生PI的独立危险因素.
Abstract
Objective To explore the influencing factors of chronic obstructive pulmonary disease(COPD)with pulmonary infection(PI)and the changes of serum interleukin-16(IL-16),CD40 and high mobility group protein B1(HMGB1).Methods The clinical data of 113 patients with COPD who received treatment in our hospital from July 2020 to June 2023 were retrospectively analyzed,and the patients were divided into infected group(34 cases)and non-infected group(79 cases)according to whether PI occurred.General data of patients were collected,and serum levels of IL-16,CD40 and HMGB1 were compared between the two groups of patients,and the risk factors of PI in patients with COPD were analyzed by univariate analysis and logistics regression analysis.Results The incidence rate of PI in patients with COPD was 30.09％(34/113).The levels of IL-16,CD40 and HMGB1 in infected group were higher than those in non-infected group(all P＜0.05).Logistics regression analysis showed that smoking history,diabetes mellitus history,hos-pital stay≥15 d,long-term use of antibiotics and mechanical ventilation,IL-16,CD40 and HMGB1 were independent risk factors of PI occurrence in COPD(all P＜0.05).Conclusion Smoking history,diabetes mellitus history,hospital stay≥15 d,long-term use of antibiotics and mechanical ventilation,IL-16,CD40 and HMGB1 are independent risk factors of PI occurrence in patients with COPD.
维普
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