Objective To optimize the extracting procedure for Liuweishenling Granules. Methods The optimum water extracting procedure was selected with the content and extraction efficiency of ginsenoside Re through the orthogonal experiment design and synthesizing multiple guidelines method. Results The optimum process was determined as 12 times of water refluxing and extracting 2 h for 2 times. Conclusion The optimum extraction process is reasonable, simple, convenient, and can provide theory basis for the production of Liuweishenling Granules in practice.