Hepatoprotective properties of kombucha tea against carbon tetrachloride-inducing acute liver injury in mice
Objective To evaluate the hepatoprotective propertiey of kombucha tea on carbon tetrachloride (CCl4 )inducing acute liver injuryon mice.Methods ICR mice were used in this study to compare the hepatoprotective properties of 3 different types of kom-bucha tea.The mice were intragastrically administrated with 20 or 10 mL·kg-1 kombucha tea daily for 7 days followed by a single dose of 1 mL·L-1 CCl4-oil solution intraperitoneal injection.The levels of AST and ALT in serum and MDA,GSH,T-SOD in liver homogenates were then measured invitro,and the pathological changes of the liver were compared.Results The reduction of the level of AST and ALT in mice serum and the content of liver MDA,the increase of the GSH level and T-SOD activity in liver homogenate,and improving liver pathological changes were observed on mice treated by all 3 types of kombucha tea at both admin-istrated concentrations.Conclusion Kombucha can revert the CCl4 inducing hepatotoxicity in mice,which might be attributed to the alleviation of liver oxidative damage.
NETL
NSTL
万方数据
维普
