Plackett-Burman设计结合Box-Behnken响应面法筛选草乌甲素纳米乳凝胶贴膏的处方
Screening the prescription of bulleyaconitine A nanoemulsion gel paste by Plackett-Burman design and Box-Behnken response surface methodology
何雨晓 1李丽云 2孙文强 2丁江生 2周云龙2
作者信息
- 1. 云南中医药大学,昆明 650500
- 2. 云南省药物研究所,昆明 650111;云南省中药和民族药新药创制企业重点实验室,昆明 650111
- 折叠
摘要
目的 优化草乌甲素纳米乳凝胶贴膏基质的处方.方法 在Plackett-Burman设计、最陡爬坡实验的基础上,以甘油、酒石酸、纯化水用量作为变量,以初黏力、持黏力、感官评价的综合评分为评价指标,用Box-Behnken响应面法优化草乌甲素纳米乳凝胶贴膏基质的处方.结果 最优处方为甘油用量 40.877 g,酒石酸用量 0.294 g,纯化水用量 42.491 g,综合评分为 94.937分.结论 建立的方法稳定、可靠、预测性能优良,此方法可用于优化草乌甲素纳米乳凝胶贴膏基质的处方.
Abstract
Objective To optimize the prescription of bulleyaconitine A nanoemulsion gel paste.Methods On the basis of Plackett-Burman design and the steepest climbing experiment,the dosage of glycerol,tartaric acid and purified water was used as the influencing factors,and the comprehensive score of initial viscosity,viscosity retention and sensory evaluation was used as the evaluation index.Box-Behnken response surface method was used to optimize the matrix prescription.Results The optimal prescription was 40.877 g of glycerol,0.294 g of tartaric acid and 42.491 g of purified water.The comprehensive score was 94.937.Conclusion The method is simple,feasible and predictive,and can be used to optimize the matrix formulation of bulleyaconitine A nanoemulsion gel paste.
关键词
草乌甲素/纳米乳/凝胶贴膏/Plackett-Burman设计Key words
bulleyaconitine A/nanoemulsion/gel paste/Plackett-Burman design引用本文复制引用
基金项目
云南省科技厅科技项目(2019DC008)
出版年
2024
NETL
NSTL
维普
万方数据