犀角地黄汤联合来氟米特对系统性红斑狼疮的改善作用
Effect of Xijiao Dihuang Decoction combined with leflunomide on systemic lupus erythematosus
王伟 1付军燕 2郭凤霞 3谷洪 4孙金磊5
作者信息
- 1. 安阳市中医院风湿免疫科,安阳 455000
- 2. 安阳市中医院功能科,安阳 455000
- 3. 安阳市中医院风湿科,安阳 455000
- 4. 郑州金域临床检验中心有限公司,郑州 450000
- 5. 郑州大学第一附属医院风湿免疫科,郑州 450000
- 折叠
摘要
目的 观察犀角地黄汤联合来氟米特对系统性红斑狼疮(systemic lupus erythema,SLE)的改善及对Th1/Th2失衡的影响.方法 选取123例急性活动期热毒炽盛证SLE患者,用随机数字表法分为对照组(n=61)和试验组(n=62).对照组采用醋酸泼尼松片联合来氟米特治疗,试验组在对照组治疗的基础上用犀角地黄汤治疗.比较治疗前、治疗后1个月和治疗后3个月2组疾病活动度评分、中医证候评分、补体C3水平和Th1/Th2值;比较2组抗ds-DNA抗体阳性率、临床疗效和不良反应.结果 治疗前2组SLE疾病活动度评分(SLE disease activity score,SLEDAI)、中医证候评分、补体C3水平和Th1/Th2值比较,差异无统计学意义;治疗后1、3个月试验组SLEDAI评分、中医证候评分、Th1/Th2值和抗ds-DNA抗体阳性率均明显低于对照组,补体C3水平和临床总有效率均明显高于对照组(P＜0.05);试验组不良反应发生率明显低于对照组(P＜0.05).结论 犀角地黄汤可改善急性活动期热毒炽盛证SLE患者疾病活动度及中医证候、实验室指标,提升临床疗效,减少糖皮质激素及免疫抑制剂所致的不良反应.
Abstract
Objective To observe the efficacy of Xijiao Dihuang Decoction combined with leflunomide on systemic lupus erythemato-sus(SLE)and the effect on Th1/Th2 imbalance.Methods A total of 123 patients with SLE with acute active heat-toxin flaring syn-drome who were admitted to our hospital were selected and divided into control group and experimental group by random number table method,with 61 cases and 62 cases respectively.The control group was treated with Prednisone Acetate Tablets combined with leflunomide,and the experimental group was treated with Xijiao Dihuang Decoction on the basis of the control group.The disease ac-tivity score,the traditional Chinese medicine(TCM)syndrome score,the complement C3 level,and the Th1/Th2 ratio were com-pared between the 2 groups before treatment,1 and 3 months after treatment.The anti-ds-DNA antibody positive rate,clinical effi-cacy and adverse reactions were also compared.Results There was no significant difference in SLE disease activity score(SLEDAI),TCM syndrome score,complement C3 level,and Th1/Th2 ratio between the 2 groups before treatment(P＞0.05).The SLEDAI score,TCM syndrome score,and Th1/Th2 ratio in the experimental group were significantly lower than those in the control group,and the levels of complement C3 were significantly higher than those in the control group 1 and 3 months after treatment(P＜0.05).The positive rate of anti-ds-DNA antibody in the experimental group was lower than that in the control group 1 and 3 months after treatment(P＜0.05).The clinical total effective rate in the experimental group was significantly higher than that in the control group(P＜0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(P＜0.05).Conclusion Xijiao Dihuang Decoction can decrease the disease activity,TCM syndromes and laboratory indicators of SLE patients with acute active heat-toxicity syndrome,improve clinical efficacy,and reduce adverse reactions caused by glucocorticoids and immu-nosuppressants.
关键词
犀角地黄汤/来氟米特/醋酸泼尼松片/系统性红斑狼疮/急性活动期/热毒炽盛证Key words
Xijiao Dihuang Decoction/leflunomide/Prednisone Acetate Tablets/systemic lupus erythematosus/acute active stage/heat-toxin flaring syndrome引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20190258)
出版年
2024
NETL
NSTL
维普
万方数据