Effect of carvedilol combined with nicodil on angina pectoris in patients with coronary heart disease
Objective To investigate the effects of carvedilol combined with nicodil on peripheral blood microparticles(MP),paraoxophosphorase-1(PON1)and myeloperoxidase/paraoxophosphorase-1(MPO/PON1)in patients with angina pectoris of coronary heart disease(CHD).Methods 69 patients with CHD angina pectoris were divided into observation group(n=30)and control group(n=39).The control group was given carvedilol on the basis of conventional treatment,and the observation group was given nicodil on the basis of control group.The clinical efficacy,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)and other cardiac function indexes were compared between the 2 groups.The platelet microparticles(PMP),endothelial cell derived microparticles(EMP)and erythro-cyte microparticles(RMP)were compared.The PON1 and MPO/PON1 levels,and the number and duration of angina attacks were also compared.Results The total effective rate of the observation group was 96.67%,which was significantly higher than that of the control group(79.49%,P＜0.05).After treatment,LVEF levels in observation group were significantly higher than those in control group,the LVEDD and LVESD levels were significantly lower than those in control group(P＜0.05);the PMP,EMP and RMP in observation group were significantly lower than those in control group(P＜0.05).The PON1 level in the observation group was significantly higher than that in the control group.The levels of MPO and MPO/PON1 were signifi-cantly lower than those of control group(P＜0.05).The frequency and time of angina pectoris attack in the observation group were significantly lower than those in the control group(P＜0.05).Conclusion Carvedilol combined with nicodil can enhance the clinical efficacy of CHD patients with angina pectoris,improve the cardiac function of patients,reduce the MP level in peripheral blood of patients,maintain PON1,MPO/PON1 levels,and reduce(shorten)the frequency and time of angina pectoris in patients.
NETL
NSTL
万方数据
维普
