Effect of nicorandil combined with different doses of rosuvastatin in the treat-ment of coronary slow flow
Objective To investigate the clinical efficacy of nicorandil combined with different doses of rosuvastatin in the treatment of coronary slow flow(CSF).Methods 84 patients with CSF were randomly divided into 3 groups(28 cases in each group).The con-trol group received routine treatment.The routine dose group was added with routine dose of rosuvastatin and nicorandil on the basis of the control group,and the high dose group was added with intensive dose of rosuvastatin and nicorandil on the basis of the control group.The levels of inflammatory factors,nitric oxide,endothelin-1(ET-1)and ventricular repolarization indexes were observed be-fore and after treatment.The clinical efficacy and adverse cardiovascular events(MACE)of the 3 groups were compared.Results Af-ter treatment,the levels of nitric oxide in the 3 groups significantly increased,with ET-1 and tumor necrosis factor-α(TNF-α)and decreased levels of interleukin-1(IL-1)(P＜0.05).The T peak Tend interval(Tp-e),corrected QT interval(QTc),Tpeak Tend interval/corrected QT interval(Tp-e/QTc),left antagonist descending branch(LAD),left amuscir cumflexus art(LCX),and right coronary art(RCA)coronary angiography corrected TIMI frame count(CTFC)results of conventional-dose group and high-dose group were significantly lower than those of the control group,and the level of nitric oxide was significantly higher than those of the control group(P＜0.05).However,there was no significant difference between routine dose group and high dose group.The to-tal effective rate of the control group was significantly lower than that of the other 2 groups,and the incidence of MACE was signifi-cantly higher than that of the other 2 groups(P＜0.05).There was no significant difference in the total effective rate and MACE inci-dence between routine dose group and high dose group.Conclusion Nicorandil combined with rosuvastatin in the treatment of CSF can effectively accelerate coronary blood flow,inhibit inflammatory response,improve endothelial dysfunction,alleviate myocardial ischemia,improve ventricular repolarization and improve clinical efficacy.
NETL
NSTL
万方数据
维普
