Preparation of Tongshu Gel Paste and study on the transdermal penetration in vitro
Objective Tongshu prescription is a common clinical prescription for treating dysmenorrhea.In order to improve the thera-peutic effect and provide,this study improved the powder into gel ointment,and investigated its transdermal absorption performance in vitro,and provide.Methods The comprehensive evaluation standard was established,and the matrix dosage of gel paste was deter-mined by single factor experiment and response surface method.The transdermal experiment in vitro was conducted,and the effects of different proportions of azone penetration enhancers on the transdermal penetration of gel paste in vitro were investigated with tetrahydro-palmatine,paeoniflorin,tetrandrine,and linderane as evaluation indexes.Results The optimal matrixformula of Tongshu Gel Paste were as follows:sodium polyacrylate 0.50 g,aluminum glycinate 0.1 g,humectant 8.00 g(glycerol∶propylene glycol=8∶2),tartaric acid 0.1 g,sodium carboxymethyl cellulose(CMC-Na)and gelatin 1.75 g(CMC-Na∶gelatin=1∶3).The experimental results of transdermal absorption in vitro showed that the transdermal effect of drugs was the highest when the proportion of transdermal enhancers was 3％.Conclusion Tongshu Gel Paste prepared has the characteristics of skeleton sustained-release preparation,which lays a foundation for the development of new dosage forms for external use of Tongshu prescription.
gel pastematrixresponse surface methodologytransdermal test in vitroazone
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