Therapeutic effects of high-flow nasal cannula combined with dual-route adminis-tration of ambroxol on severe pneumonia complicated with respiratory failure
Objective To analyze the therapeutic effects of high-flow nasal cannula(HFNC)combined with dual-route administration of ambroxol on arterial blood gas indexes,hypersensitive C-reactive protein(hs-CRP)and pulmonary surfactant protein D(SP-D)in patients with severe pneumonia and respiratory failure.Methods A total of 92 patients with severe pneumonia and respiratory failure were selected and divided into observation group and control group by the random number table method,with 46 cases in each group.The control group was treated with dual-route administration of ambroxol(alveolar lavage and aerosol inhalation of ambroxol),while the observation group was treated with HFNC on this basis,for 7 days.The relevant clinical indexes,clinical effect,changes in arterial blood gas indexes,serum hs-CRP and SP-D levels before and after treatment were compared between the 2 groups.The occurrence of adverse reactions in both groups during treatment was recorded.Results After treatment,the mechanical ventilation time and hospital stay of the observation group were shorter than those of the control group,and the re-intubation rate was lower than that in control group(P＜0.05).The total effective rate in the observation group(89.13％)was higher than that in the control group(71.74％)(P＜0.05).The arterial partial pressure of oxygen(PaO2)and oxygen saturation(SaO2)in observation group were higher than those in control group.The arterial partial pressure of arterial carbon dioxide(PaCO2),serum hs-CRP and SP-D were lower than those in control group(P＜0.05).No serious adverse reaction was observed in either group.Conclusion HFNC combined with dual-route administration of ambroxol can effectively improve arterial blood gas indexes,reduce inflammatory response,further improve cu-rative effect and promote recovery of patients with severe pneumonia and respiratory failure.
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