Prevention effect of warfarin combined with atorvastatin on cerebral thrombosis in patients with atrial fibrillation
Objective To explore the prevention effect of warfarin combined with atorvastatin on cerebral thrombosis in patients with atrial fibrillation(AF).Methods According to different intensity of warfarin,90 patients with AF were divided into low-intensity group(n=45)and standard intensity group(n=45),both groups were treated with atorvastain,and the low-intensity group was initially treated with warfarin 1.25 mg,the standard international normalized ratio(INR)range was 1.5-2.1.The standard-intensity group began to receive 2.5 mg of warfarin,with an INR compliance range of 2.2-2.7.All patients were followed up for 1 year.The coagulation function indexes,clinical composite endpoint events,safety endpoint events,INR and maintenance dose of warfarin were compared between the 2 groups before and after treatment.Results After treatment,the fibrinogen(FIB),activated partial thromboplastin time(APTT)and prothrombin time(PT)in both groups were higher(longer)than before tretment(P＜0.05),but there was no significant difference between the 2 groups(P＞0.05).There was no significant difference in the incidence of clinical composite endpoint events between the 2 groups(P＞0.05).The incidence rates of gingival bleeding and skin mucosa bleeding in low-intensity group were 4.44％and 8.89％,lower than those in standard-intensity group(17.78％,24.44％,P＜0.05).The INR and maintenance dose of warfarin in low-intensity group were lower than those in standard-intensity group(P＜0.05).Conclusion Different intensity of warfarin combined with atorvastatin for anticoagulant therapy has similar curative effect in AF patients.The 2 methods have similar clinical composite endpoint time incidence rates.However,low-intensity warfarin combined with atorvastatin is beneficial to prevent bleeding.
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