Effects of sacubitril-valsartan combined with spironolactone on cardiac function in elderly patients with mental failure and decreased ejection fraction
Objective To investigate the efficacy of sacubitril-valsartan combined with spironolactone and metoprolol tartrate in the treatment of elderly patients with mental failure and decreased ejection fraction(HFrEF),and its effects on cardiac function and the level of serum N-terminal pro brain natriuretic peptide(NT proBNP).Methods A total of 120 elderly patients with HFrEF were se-lected as the research subjects,and divided into control group(60 cases)and observation group(60 cases)by random number table method.The both groups were given routine treatment.The control group was given Spironolactone Tablets combined with Metopro-lol Tartrate Tablets,and the observation group was given Sacubitril Valsartan Sodium Tablets on the basis of the control group,treated continuously for 2 months.The clinical efficacy of the 2 groups after 2 months of treatment,the 6-minute walking test dis-tance(6MWT),urine volume,myocardial evaluation parameters,and the levels of serum NT-proBNP,aldosterone,serum creati-nine before and after 2 months of treatment,readmission rates and adverse reactions during the treatment between the 2 groups were compared.Results After 2 months of treatment,the total effective rate in the observation group(91.67％)was higher than in the con-trol group(76.67％),P＜0.05.Compared with before treatment,the 6MWT,urine volume,left ventricular ejection fraction(LVEF),cardiac output per minute(CO)and cardiac output index(CI)in the 2 groups all increased,and the observation group was higher than the control group;the heart rate(HR),the levels of serum NT-proBNP and aldosterone in both groups decreased,and the observation group was lower than the control group(P＜0.05).During the treatment period,the readmission rate in the observa-tion group(13.33％)was lower than the control group(30.00％),P＜0.05.There was no significant difference between the observa-tion group(13.33％)and the control group(15.00％)in the incidence of adverse reactions.Conclusion Sacubitril-valsartan com-bined with spironolactone and metoprolol tartrate could effectively improve the cardiac function and the level of serum NT-proBNP in elderly patients with HFrEF,increased the patient's 6MWT,and reduced the patient's readmission rate with good safety.
sacubitril-valsartanspironolactoneheart failureejection fractioncardiac function
NETL
NSTL
万方数据
