Research progress in the chemical constituents of Nardostachys jatamansi DC.and its pharmacological activities
Objective A systematic review was conducted on the chemical constituents and pharmacological activities of Nardostachys jatamansi DC.(N.jatamansi)over the past 5 years.This review offers a point of reference for the exploration of active components,pharmacology,toxicology,and clinical applications of N.jatamansi.Methods Based on the 2020 edition of the Chinese Pharmaco-poeia,various databases including CNKI,PubMed,Wanfang,Jinglun Knowledge Resource System,and others were searched.Re-sults There were 64 newly discovered chemical constituents,including sesquiterpenes,pentacyclic triterpenes,iridoids and lignans in the last 5 years.Modem pharmacological studies showed that the extracts and active ingredients of N.jatamansi have a wide range of biological activities,including neuromodulation,anti-inflammatory,antibacterial,antioxidant,and regulation of metabolism.Among them,the clinical application is remarkable,mainly focusing on the treatment of cardiovascular system diseases such as arrhythmia,an-gina pectoris,coronary heart disease and diabetes mellitus.Conclusion N.jatamansi is a commonly used Tibetan medicine with a wide range of biological activities and a complex composition.The herb has good clinical application.
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