补虚化瘀组方治疗原发性胆汁性胆管炎的效果
Effect of Buxu Huayu Prescription in the treatment of primary biliary cholangitis
张祯捷 1黄洋 1张玮1
作者信息
- 1. 上海中医药大学附属龙华医院感染科,上海 200032
- 折叠
摘要
目的 探究补虚化瘀组方对原发性胆汁性胆管炎(primary biliary cholangitis,PBC)中医临床症状及免疫功能的影响.方法 选取80例PBC患者作为研究对象,用单双球法随机分为对照组和治疗组,每组40例.对照组给予基础治疗,治疗组在基础治疗的基础上予以补虚化瘀组方治疗.比较治疗前和治疗6个月后,2组患者中医症候积分(腹胀、胁肋疼痛、乏力、皮肤瘙痒及大便不调)、肝功能指标[天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、谷氨酰转肽酶(glutamyl transpeptidase,GGT)、碱性磷酸酶(alkaline phosphatase,ALP)及总胆红素(total bilirubin,TB)]、免疫功能[免疫细胞(CD4+、CD8+)、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)及免疫球蛋白M(immunoglobulin M,IgM)],记录2组患者不良反应(头晕、恶心呕吐、腹泻及皮疹)的发生情况.结果 治疗6个月后,2组患者的中医症候积分、肝功能指标及免疫功能均降低,且治疗组低于对照组(均 P<0.05);6 个月内,治疗组熊去氧胆酸(ursodeoxycholic acid,UDCA)应答率高于对照组(P<0.05),2组患者总不良反应发生率比较差异无统计学意义(P>0.05).结论 补虚化瘀组方可以改善PBC患者中医临床症状及肝功能,增强患者免疫力,减少不良反应的发生.
Abstract
Objective To explore the influence of Buxu Huayu Prescription on clinical traditional Chinese medicine(TCM)symptoms and immune function in the treatment of primary biliary cholangitis(PBC).Methods 80 patients with PBC were selected as the research subjects,and were randomly divided into control group(n=40)and treatment group(n=40)by single-double ball method.The control group was given basic treatment,while the treatment group received Buxu Huayu Prescription on the basis of basic treatment.The TCM symptoms scores(abdominal distention,hypochondriac pain,fatigue,skin itching and irregular stool),liver function indicators[aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP)and total bilirubin(TB)]and immune function[immune cells(CD4+,CD8+),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)]were compared between the 2 groups before treatment and after 6 months of treatment,and the adverse reactions(dizziness,nausea and vomiting,diarrhea and rash)of the 2 groups of patients were recorded within 6 months.Results After 6 months of treatment,the scores of TCM symptoms,liver function indicators and immune function in the 2 groups were decreased,and the above indicators in treatment group were lower than those in control group(all P<0.05).At 6 months,the ursodeoxycholic acid(UDCA)response rate was higher in the treatment group than in the control group(P<0.05).There was no statistical significance in the total adverse reaction rate between the 2 groups(P>0.05).Conclusion Buxu Huayu Prescription can improve the clinical TCM symptoms and liver function,enhance the immune function,and reduce the occurrence of adverse reactions of patients with PBC.
关键词
补虚化瘀组方/原发性胆汁性胆管炎/中医临床症状/免疫功能Key words
Buxu Huayu Prescription/primary biliary cholangitis/clinical TCM symptoms/immune function引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据