Effect of Buxu Huayu Prescription in the treatment of primary biliary cholangitis
Objective To explore the influence of Buxu Huayu Prescription on clinical traditional Chinese medicine(TCM)symptoms and immune function in the treatment of primary biliary cholangitis(PBC).Methods 80 patients with PBC were selected as the research subjects,and were randomly divided into control group(n=40)and treatment group(n=40)by single-double ball method.The control group was given basic treatment,while the treatment group received Buxu Huayu Prescription on the basis of basic treatment.The TCM symptoms scores(abdominal distention,hypochondriac pain,fatigue,skin itching and irregular stool),liver function indicators[aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP)and total bilirubin(TB)]and immune function[immune cells(CD4+,CD8+),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)]were compared between the 2 groups before treatment and after 6 months of treatment,and the adverse reactions(dizziness,nausea and vomiting,diarrhea and rash)of the 2 groups of patients were recorded within 6 months.Results After 6 months of treatment,the scores of TCM symptoms,liver function indicators and immune function in the 2 groups were decreased,and the above indicators in treatment group were lower than those in control group(all P<0.05).At 6 months,the ursodeoxycholic acid(UDCA)response rate was higher in the treatment group than in the control group(P<0.05).There was no statistical significance in the total adverse reaction rate between the 2 groups(P>0.05).Conclusion Buxu Huayu Prescription can improve the clinical TCM symptoms and liver function,enhance the immune function,and reduce the occurrence of adverse reactions of patients with PBC.
Buxu Huayu Prescriptionprimary biliary cholangitisclinical TCM symptomsimmune function
NETL
NSTL
万方数据
维普
