Improvement of vascular endothelial function and neurological function in patients with acute cerebral infarction treated with butylphthalide
Objective To analyze the improvement of vascular endothelial function and neurological function in patients with acute cerebral infarction treated with butylphthalide.Methods 136 patients with acute cerebral infarction were randomly divided into edaravone group(68 cases)and combined butylphthalide group(68 cases)by random number table method.The both groups received conventional treatment,and on this basis,the edaravone group was treated with Edaravone Injections,and the combined butylphthalide group was treated with Butylphthalide Injections on the basis of the edaravone group.The both groups were treated for 2 weeks.The clinical efficacy after 2 weeks of treatment was statistically analyzed.The vascular endothelial function,inflammation,oxidative stress index,nerve injury index,neurological function,cognitive function and life ability were compared between the 2 groups before and after 2 weeks of treatment.Results After 2 weeks of treatment,the total effective rate of the combined butylphthalide group was higher than that of the edaravone group(P<0.05).After 2 weeks of treatment compared with before treatment,the levels of serum angiopoietin-1(ANG-1),endothelin-1(ET-1),thromboxene A2(TXA2),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),lipoprotein phospholipase A(Lp-PLA2),neuron-specific enolase(NSE)fibrillary acidic protein(GFAP),S100β and the score of National Institutes of Health Stroke Scale(NIHSS)and neuropathy disability score(NDS)decreased in the 2 groups.The combined butylphthalide group were lower than the edaravone group(P<0.05).The levels of serum vascular endothelial growth factor(VEGF)and superoxide dismutase(SOD),and the scores of activities of daily living(ADL)and Montreal cognitive assessment(MoCA)in the 2 groups increased.The combined butylphthalide group were higher than the edaravone group(P<0.05).Conclusion Combined with butylphthalide in the treatment of patients with acute cerebral infarction could more effectively improve the vascular endothelial function of patients,reduce inflammation and oxidative stress response,improve the neurological function,cognitive function and life ability of patients.
butylphthalideedaravoneacute cerebral infarctionvascular endothelial functionfunction of nerves
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NSTL
万方数据
维普
