丁苯酞对急性脑梗死患者血管内皮功能和神经功能的改善
Improvement of vascular endothelial function and neurological function in patients with acute cerebral infarction treated with butylphthalide
刘博会 1焦慧娟 1刘俊平 1胡世玉1
作者信息
- 1. 驻马店市中心医院神经内一科,驻马店 463000
- 折叠
摘要
目的 分析急性脑梗死患者经丁苯酞治疗后血管内皮功能和神经功能的改善情况.方法 将收治的136例急性脑梗死患者随机分为依达拉奉组和联合丁苯酞组,每组68例.2组均进行常规治疗,在此基础上,依达拉奉组用依达拉奉注射液治疗,联合丁苯酞组在依达拉奉组治疗的基础上加用丁苯酞注射液治疗,2组均治疗2周.统计治疗后的临床疗效,比较2组治疗前和治疗2周后的血管内皮功能、炎症、氧化应激、神经损伤指标,神经功能,认知功能及生活能力.结果 治疗2周后,联合丁苯酞组的总有效率为91.18%,高于依达拉奉组(77.94%),P<0.05.与治疗前比较,2 组血清促血管生成素-1(angiopoietin-1,ANG-1)、内皮素-1(endothelin-1,ET-1)、血栓素A2(thromboxene A2,TXA2)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、丙二醛(malondialdehyde,MDA)、脂蛋白磷脂酶A(lipoprotein phospholipase A,Lp-PLA2)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)、S100β、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)及神经病残疾评分(neuropathy disability score,NDS)均降低,且联合丁苯酞组低于依达拉奉组(P<0.05);2组血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、超氧化物歧化酶(superoxide dismutase,SOD)、日常生活活动(activities of daily living,ADL)及蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分均升高,且联合丁苯酞组高于依达拉奉组(P<0.05).结论 用丁苯酞治疗急性脑梗死,可更有效地改善患者的血管内皮功能,降低机体炎症、氧化应激反应,改善患者的神经功能、认知功能及生活能力.
Abstract
Objective To analyze the improvement of vascular endothelial function and neurological function in patients with acute cerebral infarction treated with butylphthalide.Methods 136 patients with acute cerebral infarction were randomly divided into edaravone group(68 cases)and combined butylphthalide group(68 cases)by random number table method.The both groups received conventional treatment,and on this basis,the edaravone group was treated with Edaravone Injections,and the combined butylphthalide group was treated with Butylphthalide Injections on the basis of the edaravone group.The both groups were treated for 2 weeks.The clinical efficacy after 2 weeks of treatment was statistically analyzed.The vascular endothelial function,inflammation,oxidative stress index,nerve injury index,neurological function,cognitive function and life ability were compared between the 2 groups before and after 2 weeks of treatment.Results After 2 weeks of treatment,the total effective rate of the combined butylphthalide group was higher than that of the edaravone group(P<0.05).After 2 weeks of treatment compared with before treatment,the levels of serum angiopoietin-1(ANG-1),endothelin-1(ET-1),thromboxene A2(TXA2),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),lipoprotein phospholipase A(Lp-PLA2),neuron-specific enolase(NSE)fibrillary acidic protein(GFAP),S100β and the score of National Institutes of Health Stroke Scale(NIHSS)and neuropathy disability score(NDS)decreased in the 2 groups.The combined butylphthalide group were lower than the edaravone group(P<0.05).The levels of serum vascular endothelial growth factor(VEGF)and superoxide dismutase(SOD),and the scores of activities of daily living(ADL)and Montreal cognitive assessment(MoCA)in the 2 groups increased.The combined butylphthalide group were higher than the edaravone group(P<0.05).Conclusion Combined with butylphthalide in the treatment of patients with acute cerebral infarction could more effectively improve the vascular endothelial function of patients,reduce inflammation and oxidative stress response,improve the neurological function,cognitive function and life ability of patients.
关键词
丁苯酞/依达拉奉/急性脑梗死/血管内皮功能/神经功能Key words
butylphthalide/edaravone/acute cerebral infarction/vascular endothelial function/function of nerves引用本文复制引用
基金项目
河南省医学科技攻关计划项目(LHGJ20210021)
出版年
2024
NETL
NSTL
维普
万方数据